Table 1 Anthropometric and baseline laboratory values of the study population at screening

Age (yr)

35.7 ± 3.9

32.0 ± 2.2

43.7 ± 3.8

0.0272

Sex (M/F)

5/3

6/2

4/4

0.2059^a

Height (cm)

177.1 ± 5.7

182.2 ± 1.8

170.8 ± 4.5

0.1064

Weight (kg)

81.8 ± 4.9

75.9 ± 3.4

95.3 ± 3.9

0.0001

BMI (kg/m²)

25.7 ± 1.0

22.7 ± 1.2

32.3 ± 0.5

<.0001

Waist circumference (cm)

87.1 ± 3.7

83.3 ± 4.5

106.3 ± 4.5

0.0005

Glucose (mg/dL)

85.3 ± 1.9

84.3 ± 1.5

99.1 ± 2.4

<.0001

Insulin (ulU/mL)

61.7 ± 12.9

57.4 ± 7.9

52.9 ± 8.9

0.5917

Free Fatty Acids (mmol/L)

0.57 ± 0.06

0.26 ± 0.03

0.43 ± 0.04

0.7864

Triglycerides (mg/dL)

90.0 ± 10.6

118.7 ± 30.5

128.0 ± 15.6

0.3619

Thyroid-Stimulating Hormone (mlu/L)

2.04 + 0.38

1.69 ± 0.21

1.79 ± 0.26

0.8308

Creatine Phosphokinase (lu/L)

89.8 ± 14.2

102.6 ± 19.2

123.8 ± 19.8

0.2145

 Total body mass (kg)

81.5 ± 6.8

76.5 ± 4.7

96.5 ± 5.7

0.0219

 Total lean mass (kg)

52.3 ± 5.2

52.8 ± 3.0

54.7 ± 4.8

0.6907

 Total fat mass (kg)

26.1 ± 2.9

20.7 ± 2.8

38.6 ± 1.8

0.0001

 Visceral adipose tissue mass (g)

742.50 ± 173.87

518.63 ± 222.32

1262.63 ± 167.13

0.012

 % Body fat

32.3 ± 3.1

26.7 ± 2.5

40.7 ± 2.1

0.003

 Glucose effectiveness (S_G)

0.0201 ± 0.0031

0.0205 ± 0.0043

0.0165 ± 0.0021

0.344

 Insulin sensitivity (S_I)

4.9 ± 0.9

5.4 ± 0.8

3.8 ± 1.1

0.2569

 Acute insulin response to glucose (AIR_g)

385.1 ± 110.8

279.0 ± 32.6

497.4 ± 177.4

0.3883