Fig. 1
From: B-cell antibody class switchings are pressuromodulated events: Part II, gene recombination
Allele 1 (IGHM) 2-step and 1-step Ig heavy chain locus gene rearrangement recombination steps superimposed on the pressuromodulation map of B-cell differentiation stages. The Allele 1 two-step recombination steps are IGHD1–20 (nf) and IGHJ5 recombination (step 1 of 2), IGHD_-_ genes with respect to D1–20(nf)-J5 (step 2a of 2) and IGHJ6 with respect to D1–20(nf)-J5 (step 2a of 2) recombination that results that results in IGHD_-_-IGHJ6 (step 2b of 2) through the final IGHV_-_ and IGHD_-_-IGHJ6 recombination that results in V_-_-DJ6. The Allele 1 one-step recombination step is IGHD_-_ and IGHJ5 recombination that results in IGHD_-_-IGHJ5 (step 1 of 1) through the final IGHV_-_ and IGHD_-_-J5 recombination that results in V_-_-DJ6. Note: Allele 1 locus rearrangement recombination steps complete to the point of the CM IgM+ B-cell before Allele 2 VDJ completes. †, upper esebssiwaagoTQ units range, 0.41–0.36. Black, CD40 at maximum cell polarization potential. Dark blue, CD40 at half-refractory. Light blue, CD40 at full-refractory. Text boxes with complete borders, 2-step. Text boxes with dashed borders, 1-step. Large rectangular box with complete borders, extra-nodal secretory antibody phase