Fig. 4

Changes in the amount of excreted total aceneuramic acid in urine (Trial-1). Urine was collected in periods of − 24 to 20 h and - 20 to 0 h (before administration), 0 to 4 h and 4 to 24 h (after administration). The amount of excreted total aceneuramic acid was compared between before and after administration. In single and three times per day administration, the amount of excretion for 24 h increased after administration in all but one subject (subject number 1). In 5-day administration, the total aceneuramic excretion of 24 h increased after administration. a. Single administration (subject numbers 1 to 3), Three-times-per-day administration (subject numbers 4 to 6). b. Three-times-per-day administration for 5 days (subject numbers 2, 4 and 6). BF: before administration, AF: after administration, D 1: day 1 of administration, D 5: day 5 of administration