Fig. 2

Suppressive capacity of PMN-MDSCs and correlation with PMN-MDSC frequencies. (a + b + c) The suppressive capacity of PMN-MDSCs correlates inversely and significantly with the PMN-MDSC frequencies in all subjects (rho = 0.51, p = 0.0082) (a) and in progressors (PR) (rho = 0.87, p = 0.0022) (b), whereas there is no significant correlation in controllers (CO) (rho = 0.90, p = 0.083) (c). (d + e) The suppressive capacity is significantly lower in subjects with PMN-MDSC frequencies above 2.5% compared to subjects with frequencies below 2.5% in all subjects (p = 0.021) (d) and in PR subjects (p = 0.016) (e). All controllers have PMN-MDSC frequencies below 2.5% (e). [all subjects: n = 26; PR: n = 10; CO: n = 5; HC: n = 5; BRO: n = 6]