Fig. 2
From: Transcriptional and free radical responses to LVAD therapy
Pathway analysis in IPA. Upstream analysis in IPA of fold change genes in Pre and Post compared to control. DNA methylation signals were upregulated in both pre- and post-LVAD with a Z-score of 2.00 and 2.36 for DNMT3A and DNMT3B, respectively. Inhibition of mir21 was observed with a Z-score of − 2.00 in Post LVAD. Dashed line (indirect interaction with other molecules), solid line (direct interaction with other molecules)