Fig. 10

Proposed EoE diagnostic technology: µOCT imaging (a)-(c) and H&E histology (d)-(f) results from an EoE biopsy study. Biopsies from EoE patients were imaged within 60 minutes after being obtained by routine WLE guidance. a and b depict exemplary EoE negative (no eosinophils) and EoE positive intensity scans, respectively. d and e depict corresponding histology results. The hyperreflective small spherical structures in (B) were confirmed to be eosinophils by histology (e). c and f present magnifications of the indicated areas in (b) and (e) showing individual eosinophils. g-i depict PS-µOCT imaging results from a first esophageal tissue study in swine, ex vivo. g depicts the squared intensity image clearly indicating the epithelium (EP), lamina propria (LP), muscularis mucosa (MM), sub-mucosa (SM) and muscularis externa (ME). h depicts the corresponding phase retardation image highlighting lamina propria as birefringence expressing layer (natural collagen content). i depicts the corresponding H&E histology showing the same layered structure as the PS-µOCT images. Scale bars: 100 µm