Table 1 Hematology and systemic inflammatory responses
Indices | Baseline | Time | Saline Control | ALM |
|---|---|---|---|---|
Granulocytes x 109cells/L | 3.0 ± 2.0 | 4 h | 5.4 ± 1.9 | 8.6 ± 2.1*^ |
day 1 | 6.4 ± 2.8 | 8.3 ± 1.2* | ||
day 3 | 2.8 ± 1.5 | 4.9 ± 1.6^ | ||
day 5 | 2.7 ± 1.6 | 3.3 ± 1.2 | ||
day 28 | 2.1 ± 1.3 | 2.7 ± 1.4 | ||
Monocytes x 109cells/L | 0.5 ± 0.7 | 4 h | 0.3 ± 0.2 | 0.6 ± 0.7 |
day 1 | 0.8 ± 0.4 | 0.8 ± 0.3 | ||
day 3 | 0.4 ± 0.7 | 1.1 ± 1.0 | ||
day 5 | 0.4 ± 0.8 | 1.1 ± 0.8 | ||
day 28 | 0.4 ± 0.5 | 0.6 ± 0.6 | ||
Granulocyte:Monocyte ratio | 23.4 ± 17.7 | 4 h | 41.2 ± 35.6 | 37.1 ± 35.6 |
day 1 | 13.8 ± 13.0 | 12.2 ± 8.4 | ||
day 3 | 30.2 ± 22.7 | 15.8 ± 22.6 | ||
day 5 | 21.2 ± 15.8 | 10.4 ± 16.3*^ | ||
day 28 | 22.3 ± 20.9 | 16.1 ± 17.5 | ||
Monocyte:Lymphocyte ratio | 0.06 ± 0.09 | 4 h | 0.12 ± 0.12 | 0.18 ± 0.21 |
day 1 | 0.22 ± 0.1* | 0.17 ± 0.07 | ||
day 3 | 0.06 ± 0.08 | 0.14 ± 0.12 | ||
day 5 | 0.06 ± 0.08 | 0.12 ± 0.07*^ | ||
day 28 | 0.08 ± 0.09 | 0.08 ± 0.07 | ||
IL-1β, pg/ml | 5.7 ± 3.8 | 4 h | 8.6 ± 7.1 | 9.7 ± 12.9 |
day 1 | 6.1 ± 2.5 | 10.6 ± 8.8 | ||
day 3 | 3.9 ± 2.2 | 5.7 ± 2.3 | ||
day 5 | 2.9 ± 2.4 | 5.0 ± 5.3 | ||
day 28 | 17.0 ± 12.9* | 7.4 ± 4.2^ | ||
IFN-γ, pg/ml | n.d.a | 4 h | 52.5 ± 24.6* | 32.7 ± 21.3* |
day 1 | 43.2 ± 31.6* | n.d. | ||
day 3 | 33.1 ± 24.4 | n.d. | ||
day 5 | 24.7 ± 5.6 | 23.6 ± 2.0 | ||
day 28 | n.d. | n.d. | ||
IL-10, pg/ml | 16.3 ± 10.3 | 4 h | 60.4 ± 30.0* | 67.1 ± 54.9* |
day 1 | 37.4 ± 12.4* | 46.4 ± 30.9* | ||
day 3 | 40.1 ± 15.7* | 42.7 ± 12.8* | ||
day 5 | 32.0 ± 9.9* | 21.7 ± 15.0^ | ||
day 28 | 53.7 ± 33.9* | 25.0 ± 14.2^ |