Table 6 Genotypes and allele frequencies of ACE rs4646994, ATG rs699 and AGTR1 rs5186 polymorphisms in non-severe and severe COVID-19 patients

ACE rs4646994

Codominant

DD

84 (55.3)

60 (56.6)

1.00

–

1.00

–

ID

58 (38.2)

31 (29.2)

1.33 (0.77–2.31)

0.18

1.12 (0.57–2.21)

0.42

II

10 (6.6)

15 (14.2)

0.47 (0.20–1.13)

0.06

0.70 (0.14–3.45)

0.49

Dominant

DD

84 (55.3)

60 (56.6)

1.00

–

1.00

–

ID + II

68 (44.7)

46 (43.4)

1.05 (0.64–1.74)

0.46

1.06 (0.55–2.05)

0.48

Recessive

DD + ID

142 (93.4)

91 (85.8)

1.00

–

1.00

–

II

10 (6.6)

15 (14.2)

0.42 (0.18–0.99)

0.03

0.66 (0.13–3.19)

0.46

Overdominant

DD + II

94 (61.8)

75 (70.8)

1.00

–

1.00

–

ID

58 (38.2)

31 (29.2)

1.49 (0.87–2.53)

0.08

1.16 (0.59–2.25)

0.39

Alleles

D

226 (74.5)

151 (75.0)

1.00

–

1.00

–

I

78 (25.50)

61 (25.0)

0.85 (0.57–1.26)

0.24

0.99 (0.58–1.68)

0.54

ATG rs699

Codominant

TT

8 (6.3)

12 (13.3)

1.00

–

1.00

–

TC

119 (93.7)

78 (86.7)

2.28 (0.89–5.85)

0.06

2.33 (0.75–7.14)

0.11

Alleles

T

135 (53.15)

102 (56.67)

1.00

–

1.00

–

C

119 (46.85)

78 (43.44)

1.15 (0.78–1.69)

0.26

1.16 (0.70–1.90)

0.31

ATGR1 rs5186

Codominant

AA

96 (80.0)

58 (66.7)

1.00

–

1.00

–

AC

23 (19.2)

26 (29.9)

0.53 (0.27–1.02)

0.06

0.55 (0.24–1.25)

0.11

CC

1 (0.8%)

3 (3.5)

0.20 (0.02–1.98)

0.16

0.30 (0.01–4.97)

0.41

Dominant

AA

95 (80

58 (66.7)

1.00

–

1.00

–

AC + CC

24 (20.0)

19 (35.3)

0.77 (0.38–1.52)

0.28

0.53 (0.23–1.18)

0.09

Recessive

AA + AC

119 (99.2)

84 (96.5)

1.00

–

1.00

–

CC

1 (0.8)

3 (3.5)

23 (0.02–2.30)

0.20

0.34 (0.02–5.69)

0.45

Overdominant

AA + CC

97 (80.8)

61 (70.1)

1.00

–

1.00

–

AC

23 (19.2)

26 (29.2)

0.55 (0.29–1.06)

0.052

0.56 (0.24–1.28)

0.12

Alleles

A

215 (89.58)

142 (81.61)

1.00

–

C

25 (10.42)

32 (18.39)

0.51 (0.29–0.90)

0.01

0.56 (0.27–1.14)

0.08