Table 2 Parameter of the Bioenergetic Health Index (BHI). The distinct parameter were taken before (v), after the first 10-pass OHT (n) and after the second 10-pass OHT one week later (nn). The data represent cumulative data from the respective subjects and are expressed as means + s.e.m and as median. The statistics include the t-test and the Cohen`t d test
v (n = 6) | n (n = 5) | nn (n = 6) | overall (n = 17) | |
|---|---|---|---|---|
Basal respiration [pmol O2/min] | ||||
Mean (SD) | 18.0 (5.56) | 20.0 (5.30) | 42.2 (5.44) | 27.1 (12.6) |
Median [min, max] | 18.0 [9.88, 24.2] | 20.9 [13.2, 25.9] | 41.2 [36.7, 51.4] | 23.9 [9.88, 51.4] |
t-test | 0.0000182 nn versus v; 0.561 n versus v; 0.0000884 n versus nn | |||
Cohen`s d | 4.39 nn versus v; 4.12 n versus nn | |||
Proton leak [pmol O2/min] | ||||
Mean (SD) | 1.05 (1.21) | 0.874 (0.607) | 2.20 (2.42) | 1.40 (1.66) |
Median [min, max] | 0.830 [0.00, 3.27] | 1.05 [0.00, 1.42] | 1.99 [0.00, 4.83] | 0.970 [0.00, 4.83] |
T-test | 0.33 nn versus v; 0.76 n versus v; 0.24 n versus nn | |||
Cohen`s d | 0.59 nn versus v; 0.71 n versus nn | |||
Proton leak [%] | ||||
Mean (SD) | 5.71 (6.59) | 4.46 (3.30) | 4.76 (5.28) | 5.01 (5.03) |
Median [min, max] | 4.78 [0.00, 17.80] | 5.35 [0.00, 7.99] | 4.27 [0.00, 11.00] | 5.35 [0.00, 17.80] |
T-test | 0.78 nn versus v; 0.69 n versus v; 0.91 n versus nn | |||
Cohen`s d | Not applicable | |||
Reserve capacity [pmol O2/min] | ||||
Mean (SD) | 37.80 (15.00) | 33.70 (11.20) | 96.90 (15.70) | 57.40 (32.90) |
Median [min, max] | 33.50 [20.60, 63.90] | 36.6 [17.8, 46.20] | 102 [73.10, 113] | 44.60 [17.80, 113] |
T-test | 0.0000567 nn versus v; 0.61 n versus v; 0.0000308 n versus nn | |||
Cohen`s d | 3.84 nn versus v; 4.55 n versus nn | |||
Reserve capacity [%] | ||||
Mean (SD) | 212 (33.30) | 179 (84.90) | 233 (51.20) | 210 (58.80) |
Median [min, max] | 214 [167, 263] | 141 [110, 309] | 217 [167, 307] | 214 [110, 309] |
T-test | 0.42 nn versus v; 0.45 n versus v; 0.26 n versus nn | |||
Cohen`s d | 0.47 nn versus v; 0.53 n versus v; 0.78 n versus nn | |||
Maximal respiration [pmol O2/min] | ||||
Mean (SD) | 55.80 (20.10) | 53.70 (12.80) | 139 (16.40) | 84.60 (44.40) |
Median [min, max] | 51.40 [30.50, 88.10] | 53.6 [33.9, 67.10] | 143 [117, 159] | 67.10 [30.50, 159] |
T-test | 0.000017 nn versus v; 0.83 n versus v; 0.0000047 n versus nn | |||
Cohen`s d | 4.54 nn versus v; 5.72 n versus nn | |||
Non-mitochondrial respiration [pmol O2/min] | ||||
Mean (SD) | 13.60 (8.78) | 12.20 (2.16) | 26.50 (3.25) | 17.70 (8.55) |
Median [min, max] | 13.90 [-0.88, 24.1] | 12.40 [9.72, 15.2] | 27.3 [20.8, 29.2] | 15.2 [-0.88, 29.20] |
T-test | 0.0139 nn versus v; 0.71 n versus v; 0.0000147 n versus nn | |||
Cohen`s d | 1.93 nn versus v; 5.05 n versus nn | |||
Non-mitochondrial respiration [%] | ||||
Mean (SD) | 39.0 (21.9) | 38.60 (9.20) | 38.70 (5.14) | 38.80 (13.40) |
Median [min, max] | 48.10 [-5.27, 50.20] | 37.60 [29.1, 53.7] | 39.8 [32.2, 44.3] | 40.6 [-5.27, 53.70] |
T-test | 0.97 nn versus v; 0.96 n versus v; 0.98 n versus nn | |||
Cohen`s d | Not applicable | |||
Mitochondrial ATP production [pmol O2/min] | ||||
Mean (SD) | 17.6 (6.51) | 19.20 (5.10) | 41.4 (2.94) | 26.5 (12.3) |
Median [min, max] | 16.0 [9.97, 27.6] | 19.5 [12.1, 24.5] | 40.4 [38.9, 47.0] | 23.4 [9.97, 47.0] |
T-test | 0.0000828 nn versus v; 0.66 n versus v; 0.00011 n versus nn | |||
Cohen`s d | 4.71 nn versus v; 5.49 n versus nn | |||
Coupling efficacy [%] | ||||
Mean (SD) | 98.0 (11.1) | 96.1 (3.85) | 99.2 (9.95) | 97.8 (8.63) |
Median [min, max] | 97.2 [82.2, 115] | 94.7 [92.4, 102] | 97.4 [89.0, 114] | 94.7 [82.2,115] |
T-test | 0.84 nn versus v; 0.70 n versus v; 0.505 n versus nn | |||
Cohen`s d | Not applicable | |||
BHI | ||||
Mean (SD) | 1.19 (0.637) | 1.58 (0.174) | 1.88 (0.320) | 1.55 (0.508) |
Median [min, max] | 1.34 [0.00, 1.77] | 1.59 [1.35, 1.79] | 1.93 [1.46, 2.21] | 1.60 [0.00,2.21] |
T-test | 0.045 nn versus v; 0.19 n versus v; 0.07 n versus nn | |||
Cohen`s d | 1.38 nn versus v; 0.80 n versus v; 1.15 n versus nn | |||