Table 3 Energy phenotype. The distinct parameter were taken before (v), after the first 10-pass OHT (n) and after the second 10-pass OHT one week later (nn). The data represent cumulative data from the respective subjects and are expressed as means + s.e.m and as median. The statistics include the t-test and the Cohen`t d test. OCR: oxygen comsumption rate in pmolO2/min; ECAR: extracellular acidification rate in mph/min

Respiratory quotient, basal

 Mean (SD)

7.01 (4.04)

5.34 (1.48)

2.09 (0.591)

4.78 (3.23)

 Median [min, max]

6.09 [1.65, 13.0]

6.28 [3.63, 6.55]

2.12 [1.20, 2.82]

3.82 [1.20, 13.0]

 t-test

0.03 nn versus v; 0.382 n versus v; 0.0055 n versus nn

 Cohen`s d

1.70 nn versus v; 0.52 n versus v; 3.01 n versus nn

Respiratory quotient, energy demand

 Mean (SD)

3.20 (1.21)

2.82 (0.680)

1.48 (0.321)

2.48 (1.10)

 Median [min, max]

3.29 [1.50, 5.01]

2.73 [2.22, 3.92]

1.54 [0.95, 1.91]

2.31 [0.95, 5.01]

 T-test

0.016 nn versus v; 0.53 n versus v; 0.008 n versus nn

 Cohen`s d

1.94 nn versus v; 2.62 n versus nn

Fold increase in OCR,

energy demand

 Mean (SD)

2.29 (0.52)

2.04 (0.337)

2.41 (0.211)

2.26 (0.387)

 Median [min, max]

2.07 [1.97, 3.32]

2.00 [1.69, 2.42]

2.36 [2.13, 2.71]

2.30 [1.69, 3.32]

 T-test

0.622 nn versus v; 0.37 n versus v; 0.077 n versus nn

 Cohen`s d

0.54 n versus v; 1.327 n versus nn

Fold increase in ECAR,

energy demand

 Mean (SD)

1.29 (0.343)

1.20 (0.0675)

1.87 (0.340)

1.47 (0.411)

 Median [min, max]

1.18 [1.08, 1.98]

1.20 [1.13, 1.29]

1.79 [1.53, 2.37]

1.24 [1.08, 2.37]

 T-test

0.014 nn versus v; 0.55 n versus v; 0.004 n versus nn

 Cohen`s d

1.69 nn versus v; 2.603 n versus nn