Table 1 Studies on prevalence of MTX intolerance in RA patients
S. No | Country | Sample Size (Females/ Males) | MTX Intolerance (Percentage) | Most Frequently Occurring Complaints | Major Limitations |
|---|---|---|---|---|---|
1 | Netherlands [52] | 291 patients (Female- 181, 62.19%) | 11% | Nausea ( 32.0%), Abdominal Pain (11.3%) and Behavioural Symptoms (16.5%) | Percentage of patients which discontinue MTX due to intolerance not indicated |
2 | Pakistan [38] | 150 patients (Female- 150, 100%) | 33.3% | Behavioural Symptoms (44%), Abdominal Pain (34.66%), Nausea (34%) and Fatigue (31.1%) | Female predominant small sample size |
3 | Saudi Arabia [49] | 185 patients (Female- 158, 85.4%) | 39.5% | Behavioural Complaints and Refusal to take MTX (58.37%), Nausea (37.84%) | Female predominant small sample size, mostly receiving oral MTX |
4 | Brazil [53] | 120 patients (Female- 103, 85.83%) | 21.6% | Nausea (92.3%), Abdominal Pain (46.1%) and Behavioural Symptoms (96.1%) | Small sample size and single institutional study |
5 | India [54] | 150 patients (Female- 120, 80%) | 14% | Nausea (31.7%), Abdominal Pain (14.6%), Nausea as an Anticipatory Symptom (12.2%) and Vomiting (12.2%) | • Inclusion criteria not been clearly stated • Small sample size |