Fig. 5
Suppression of Tconv proliferation by HLA-A2 CAR-Tregs pre-activated by HLA-A2 Dextramer or Dextramer blank (control). Percentage suppression of conventional T cell (Tconv) proliferation at different ratios of Tconv:Treg under different pre-activation conditions using batches of TX200-TR101 manufactured from patients with ESRD (n = 4) or healthy donors (n = 6)1. The box represents the interquartile range; the median value divides the box in two parts; whiskers represent minimum and maximum values; X represents the mean value. Individual data points (other than minimum and maximum values) are shown as open circles. No statistically significant differences in the means between the two populations (ESRD patients vs healthy donors) were observed. 1There was insufficient final product available from 4 of the healthy donors for all of the tests; consequently, the suppression assay was only conducted on 6 out of the 10 batches manufactured from healthy donor material