Table 1 IC50 of iMN013 following a single dose of iMN013 and 72 hour incubation, and following redosing every 12 hours x 6 doses
Cell Line | IC50 of iMN013 (nM) | |||
|---|---|---|---|---|
72 h Exposure | 72 h Exposure | 12 h Redosing | 12 h Redosing | |
EMT-6 | 1.25 | 1.58 | 0.22 | 0.24 |
4T1 | >100 | >100 | 0.24 | 0.35 |
DU4475 | 3.54 | 3.73 | 0.09 | 0.09 |
MCF-7 | 15.2 | 12.3 | 0.14 | 0.12 |
MDA-MB-231 | >100 | >100 | >100 | >100 |
BxPC-3 | 44 | >100 | 0.23 | 0.26 |
CFPAC-1 | 3.69 | 3.52 | 0.10 | 0.12 |
MiaPaca-2 | 8.48 | 7.81 | 0.10 | 0.10 |
SW1990 | 1.68 | 1.57 | <0.1 | <0.1 |
Renca | 6.1 | 7.7 | 0.48 | 0.55 |