Fig. 1

Characterization of UPR gene expression in the TME. A Identification via scRNAseq of cell populations from 9 glioblastoma samples. UMAP plot of all single cells. Cells are colored based on high expression of sets of marker genes for tumor cells (red), macrophages (green), oligodendrocytes (blue), and T cells (purple). B Expression of marker genes used for the identification of cluster cell types, according to Neftel et al. 2019 [25]. C UMAP plot of all single cells, colored by sample. D Feature plot depicting expression of an ER stress gene signature. E Ridge plot of signature expression. Average signature expression is shown for each cell type. Feature F and Ridge G plots depicting genes involved in UPR