Fig. 2

UPR genes differential expression and impact on patient survival. A Radar charts showing the change in expression (%) of each gene between normal brain tissue (n = 844) and glioblastoma samples (n = 408). Mann–Whitney U test was carried out comparing the microarray expression data from GEO. B Radar charts showing the change in expression (%) between low-grade glioma (n = 514) and glioblastoma samples (n = 155). Mann–Whitney U test was carried out comparing the RNA-seq expression data from TCGA cohort. The points in the chart vertices indicate a significant change in expression and the red line indicates zero change in expression. C Kaplan–Meier plots of the genes that showed a significant impact on survival using microarray data (n = 401) from the TCGA cohort. Log-rank p values are indicated. Cox proportional hazard ratio of genes with significant impact adjusted only to the clinical variable Sex (in red) and adjusted to Sex and all other genes (in blue) using D Microarray data (n = 401) and E RNA-seq data (n = 155) from TCGA