Fig. 4

Schematic representation of the main results in this work. The arrows indicate genes identified as upregulated (red) or downregulated (blue) in glioblastoma compared to normal brain samples. The shapes colored in red indicate genes identified as risk factors in the survival analyses, while protective factors are indicated in blue. The size of the arrows represents the change in expression, and the size of the shapes indicates how many survival analyses identified that gene as significant. On the left, a representative tumor with the four cell types identified from the scRNA-seq data and the potential association between XBP1 and MAPK8 expression with the presence of immune cells is shown. ATF6c: cleaved ATF6; XBP1s: spliced XBP1. Adapted from “UPR Signaling (ATF6, PERK, IRE1)”, by BioRender.com (2022). Retrieved from https://app.biorender002Ecom/biorender-templates