Fig. 2

Dependence of esophageal lamina propria morphology on eosinophilic esophagitis (EoE) status. a Mean normalized second harmonic generation images of esophageal lamina propria from nine patients depict morphological differences in the collagen fiber matrix that are dependent on EoE activity status (Scale bar: 50 μm). Arrows point to pores and arrow heads point to fibers. b Esophageal lamina propria fiber width (µm) extracted using a ridge detection algorithm is significantly higher in active EoE (aEoE) compared to non-EoE controls. c Fiber coverage (%) is significantly higher in inactive EoE (iEoE) compared to aEoE. d Lamina propria pore area (µm²) and e pore density (# pores / mm²) are significantly different in aEoE compared to iEoE and non-EoE controls. Box plot displays median line across the box and mean line in black with a center mark, while the top and bottom of the box represent the 25th and 75th percentiles. The whiskers represent the farthest data points not considered an outlier (1.5× the respective interquartile range). (* p < 0.05, ** p < 0.01, *** p < 0.005)