Fig. 4

Interstitial macrophages and eGFR at the time of biopsy and end of follow-up. Glomerular CD68 positive cells and interstitial CD68 positive cells in the cortical area per HPF were evaluated in IgAN biopsies as described in Materials and Methods. a No correlation was observed between the number of glomerular macrophages and eGFR at the time of biopsy (r = −0.99, P = 0.5, n = 32). b A significant inverse correlation was present between the number of interstitial macrophages and eGFR at the time of biopsy (r = −0.463, P < 0.008, n = 32). c No correlation was observed between the number of glomeruli and eGFR at the end of follow-up (r = −0.9, P = 0.3, n = 21). d A significant inverse correlation was present at the end of follow-up between the number of interstitial macrophages and eGFR (r = −0.474, P < 0.03, n = 21)