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  1. Vanishing white matter disease (VWMD) is a rare disease caused by mutations of the guanine exchange factor eIF2B. VWMD typically presents with juvenile onset, and there are few treatments for the disease. Rece...

    Authors: Neville Ng, Mauricio Castro Cabral-da-Silva, Simon Maksour, Tracey Berg, Martin Engel, Dina M. Silva, Dzung Do-Ha, Jeremy S. Lum, Sonia Sanz Muñoz, Nadia Suarez-Bosche, Claire H. Stevens and Lezanne Ooi
    Citation: Translational Medicine Communications 2020 5:18
    Content type: Research Published on:

  2. SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two million people in the United States. While many people recover from the virus uneventfully, a s...

    Authors: William R. Hartman, Aaron S. Hess and Joseph P. Connor
    Citation: Translational Medicine Communications 2020 5:17
    Content type: Research Published on:

  3. Translational research carries over fundamental laboratory research findings into clinical and community settings in order to ‘translate’ the findings into practice. In addition to its potential in acceleratin...

    Authors: Ajib Diptyanusa and Mubasysyir Hasanbasri
    Citation: Translational Medicine Communications 2020 5:16
    Content type: Commentary Published on:

  4. COVID-19 is an infectious disease caused by the SARS-CoV-2 virus that can affect lung physiology encompassing a wide spectrum of severities, ranging from asymptomatic and mild symptoms to severe and fatal case...

    Authors: Carla J. Goldin, Ramiro Vázquez, Fernando P. Polack and Damian Alvarez-Paggi
    Citation: Translational Medicine Communications 2020 5:15
    Content type: Review Published on:

  5. Patients with rheumatoid arthritis (RA) represent one of the fragile patient groups that might be susceptible to the critical form of the coronavirus disease − 19 (COVID-19). On the other side, RA patients hav...

    Authors: Mahmood Y. Hachim, Ibrahim Y. Hachim, Kashif Bin Naeem, Haifa Hannawi, Issa Al Salmi and Suad Hannawi
    Citation: Translational Medicine Communications 2020 5:14
    Content type: Research Published on:

  6. Infectious bronchitis (IB) is a highly contagious respiratory disease in chickens and produces economic loss within the poultry industry. This disease is caused by a single stranded RNA virus belonging to Cron...

    Authors: Eman A. Awadelkareem and Sumaia A. Ali
    Citation: Translational Medicine Communications 2020 5:13
    Content type: Research Published on:

  7. Available studies are lacking in analysis of baseline demographics and hospital presentation of patients at risk of expiring due to coronavirus disease 2019 (COVID-19), particularly Black American patients. We...

    Authors: James Andrew McCracken, Mohamed Nakeshbandi, Jeffrey Arace, Wayne J. Riley and Roopali Sharma
    Citation: Translational Medicine Communications 2020 5:12
    Content type: Research Published on:

  8. Surgical cryothermia and radiofrequency (RF) ablations for atrial fibrillation (AF) seem to result in similar sinus rhythm restoration, but the biochemical consequences of the two methods are unclear. We aimed...

    Authors: Gabriella Boano, Meriam Åström Aneq, Giannis Spyrou, Helena Enocsson, Emmanouil Charitakis and Farkas Vánky
    Citation: Translational Medicine Communications 2020 5:11
    Content type: Research Published on:

  9. The bioelectric impedance analysis permits to estimate electrical parameters and body composition of subjects who are either apparently healthy or sick with different pathologies. The aim of this study is to i...

    Authors: Taira Teresa Batista Luna, Maraelys Morales González, Manuel Verdecia Jarque, Tamara Rubio González, Soraida Candida Acosta Brooks, Antonio Rafael Selva Castañeda, Justa Carmen Columbié Regüeiferos, Victoriano Gustavo Sierra González and Luis Enrique Bergues Cabrales
    Citation: Translational Medicine Communications 2020 5:10
    Content type: Research Published on:

  10. Cystic fibrosis is a rare recessive monogenic disease caused by loss-of-function mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Recently developed CFTR-modulators (i.e. drugs th...

    Authors: Peter van Mourik, Sabine Michel, Annelotte M. Vonk, Jeffrey M. Beekman and Cornelis K. van der Ent
    Citation: Translational Medicine Communications 2020 5:9
    Content type: Protocol Published on:

  11. Myocardial recovery with Left ventricular assistant device (LVAD) therapy is dichotomous with some patients obtaining remission from end-stage heart failure whereas most require transplantation or remain on pu...

    Authors: Kajari Dhar, Asmini KC, Fang Qiu, Hesham Basma, Krupa K. Savalia, Jocelyn Jones, Alexandra M. Moulton, Matthew C. Zimmerman, John Um, Daniel Anderson, Marshall Hyden and Brian D. Lowes
    Citation: Translational Medicine Communications 2020 5:8
    Content type: Research Published on:

  12. Translating pharmacogenetic research findings that have shown clinical efficacy into sustainable, routine clinical care at the institutional level requires strong evidence of improved patient outcomes bolstere...

    Authors: Kenneth D. Levy, R. Ryanne Wu, Daisuke Goto, Michelle A. Ramos, Victoria M. Pratt, J. Kevin Hicks, Ebony B. Madden, Gillian C. Bell, Kathryn V. Blake, Michelle Cohen, Benjamin Q. Duong, James P. Franciosi, Lori A. Orlando, Kunal Sanghavi and Geoffrey S. Ginsburg
    Citation: Translational Medicine Communications 2020 5:7
    Content type: Research Published on:

  13. A considerable portion of the HIV pandemic is composed of people under antiretroviral therapy, many of whom get a late diagnosis. Patients starting antiretroviral therapy (ART) at a very advanced stage of HIV ...

    Authors: Dámaris P. Romero-Rodríguez, Carlos Ramírez, Iván Imaz-Rosshandler, Christopher E. Ormsby, Amy Peralta-Prado, Gustavo Olvera-García, Fernanda Cervantes, Daniela Würsch-Molina, Jessica Romero-Rodríguez, Wei Jiang, Gustavo Reyes-Terán and Enrique Espinosa
    Citation: Translational Medicine Communications 2020 5:6
    Content type: Research Published on:

  14. Diffuse large B-cell lymphoma (DLBCL) is a heterogenous blood cancer, but can be broadly classified into two main subtypes, germinal center B-cell-like (GCB) and activated B-cell-like (ABC). GCB and ABC subtyp...

    Authors: Ewan Hunter, Ronald McCord, Aroul S. Ramadass, Jayne Green, Jurjen W. Westra, Kirsten Mundt and Alexandre Akoulitchev
    Citation: Translational Medicine Communications 2020 5:5
    Content type: Research Published on:

  15. Intense exercise is a systemic stressor associated with the release of “danger” molecules – alarmins, by damaged or dying cells into systemic circulation to evoke a sterile inflammatory response. Compared with...

    Authors: Jorming Goh, Peter Hofmann, Ning Hong Aw, Poh Ling Tan, Gerhard Tschakert, Alexander Mueller, Siew Cheng Wong, Frankie Tan and Linda Seo Hwee Gan
    Citation: Translational Medicine Communications 2020 5:4
    Content type: Research Published on:

  16. Osteoarthritis is the most common joint damage that leads to cartilage destruction, pain, and disability. The aim of this study is to investigate the effects of resistance exercises and Nano curcumin supplemen...

    Authors: Sadegh Cheragh-Birjandi, Meysam Moghbeli, Farideh Haghighi, Mohammad Reza Safdari, Maryam Baghernezhad, Arash Akhavan and Reza Ganji
    Citation: Translational Medicine Communications 2020 5:3
    Content type: Research Published on:

  17. Cystic fibrosis (CF) lung disease is associated with chronic inflammation leading to progress in lung function. Adiponectin is a predominantly anti-inflammatory adipokine that may have a role in CF lung. This ...

    Authors: Atqah AbdulWahab, Mona Allangawi, Merlin Thomas, Ilham Bettahi, Siveen K. Sivaraman, Jayakumar Jerobin, Prem Chandra, Abdul-Badi Abou-Samra and Manjunath Ramanjaneya
    Citation: Translational Medicine Communications 2020 5:2
    Content type: Research Published on:

  18. Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are an immature cell type that inhibits the effector functions of T lymphocytes in chronic HIV infection. A well-known immunological feature of th...

    Authors: Eva M. Grützner, Ashley Neizert, Renate Stirner, Raffaele Conca, Immanuel Andrä, Lisa Wolff, Matthias Schiemann, Lesca M. Holdt, Christoph Klein, Johannes R. Bogner and Rika Draenert
    Citation: Translational Medicine Communications 2020 5:1
    Content type: Research Published on:

  19. Colorectal cancer (CRC) can be considered as a result of multiple risks factors, and the significant role of infectious ones, especially viral diseases could not be underestimated. Despite endorsed attempts to...

    Authors: Shaian Tavakolian, Hossein Goudarzi, Behrang Kazeminezhad and Ebrahim Faghihloo
    Citation: Translational Medicine Communications 2019 4:20
    Content type: Research Published on:

  20. Tooth hypersensitivity and pain are undesirable side effects of bleaching agents in humans. The aim of this study is to implement strategies to counter such side effects, and to demonstrate the efficacy and me...

    Authors: Diana Wang, Kawaljit Kaur, Avina Paranjpe, Eric Lee, Matthew Wasilewski, Danielle Sung, David Han, Eric C. Sung and Anahid Jewett
    Citation: Translational Medicine Communications 2019 4:19
    Content type: Research Published on:

  21. A rift that has opened up between basic research (bench) and clinical research and patients (bed) who need their new treatments, diagnostics and prevention, and this rift is widening and getting deeper. The cr...

    Authors: Attila A. Seyhan
    Citation: Translational Medicine Communications 2019 4:18
    Content type: Review Published on:

  22. We developed and clinically test a new method to manufacture mature dendritic cells for autologous cell therapy of solid and hematological malignancies.

    Authors: Leonardo Mirandola, Maurizio Chiriva-Internati, Robert Bresalier, Francesco M. Marincola, Jose A. Figueroa and Scott Dahlbeck
    Citation: Translational Medicine Communications 2019 4:17
    Content type: Research Published on:

  23. This article presents examples of how to utilize the research output, to initiate academia-industry interaction, with the ultimate task of launching a new product: a smart heart valve prosthesis for pediatric ...

    Authors: Albert R. Liberski, Jonathan T. Butcher, Zbigniew Nawrat, Tal Golesworthy and Dena Ahmed Al Thani
    Citation: Translational Medicine Communications 2019 4:16
    Content type: Research Published on:

  24. Mycoplasmas are ubiquitous pathogens found not only in humans but also in animals, plants, insects and soil. Though they usually grow better in an aerobic environment, mycoplasmas are also facultative anaerobi...

    Authors: Francesca Benedetti, Selvi Krishnan, Fiorenza Cocchi, Hervé Tettelin, Robert C. Gallo, Davide Zella and Sabrina Curreli
    Citation: Translational Medicine Communications 2019 4:15
    Content type: Research Published on:

  25. Colorectal cancer (CRC) is the third most common cancer worldwide, and its incidence is expected to increase to over 2.2 million new cases in 2030. Stage II CRC is classified as localized disease, while stage ...

    Authors: Matilda Holm, Sakari Joenväärä, Mayank Saraswat, Tiialotta Tohmola, Ari Ristimäki, Risto Renkonen and Caj Haglund
    Citation: Translational Medicine Communications 2019 4:14
    Content type: Research Published on:

  26. Even as the eukaryotic stranded DNA is known to heterochromatinize at the nuclear envelope in response to mechanical strain, the precise mechanistic basis for alterations in chromatin gene transcription in dif...

    Authors: Hemant Sarin
    Citation: Translational Medicine Communications 2019 4:13
    Content type: Research Published on:

  27. Prevalence of diabetes and comorbid brain disorders is increasing worldwide particularly in low- and middle-income countries. Diabetes and its complications impose substantial economic costs on the developing ...

    Authors: Ajit Kumar Thakur, Sakshi Tyagi and Nikhila Shekhar
    Citation: Translational Medicine Communications 2019 4:12
    Content type: Review Published on:

  28. Interleukin-17A (IL-17A) is a potent pro-inflammatory cytokine that has been implicated in the pathogenesis of various autoimmune diseases. The production of IL-17A is commonly associated with subsets of CD4+ ...

    Authors: Pradeep K. Dagur, Elena Stansky, Ankit Saxena, Angélique Biancotto and John Philip McCoy Jr
    Citation: Translational Medicine Communications 2019 4:11
    Content type: Methodology Published on:

  29. Understanding pediatric cancer biology is a huge challenge in continuous development that is currently being implemented into the clinical practice thanks to the new high throughput technologies integrated by ...

    Authors: Pablo Gargallo, Jaime Font de Mora, Pablo Berlanga, Inés Calabria, Margarita Llavador, Laia Pedrola, Joaquín Panadero, Sandra Dolz, Ángel Zúñiga, Juan Silvestre Oltra, Paloma Escobar, Yania Yáñez, María José Aparisi, Marina Martinez-Matilla, Vanessa Segura, Carlos Esquembre…
    Citation: Translational Medicine Communications 2019 4:10
    Content type: Research Published on:

  30. Endometriosis impacts 6–10% of all reproductive- age women. Studies have shown the more effectively endometriosis is removed, the better the patient outcomes for pain reduction and fertility (2, 3). Hemosideri...

    Authors: Andrew G. Cabe, Arnold D. Estrada, Taylor Hoyt, Xiao Yang, Scott Jenney, Philip T. Valente, Bryan Cox, Jessica E. McLaughlin, Randal D. Robinson, Thomas E. Milner and Marc D. Feldman
    Citation: Translational Medicine Communications 2019 4:9
    Content type: Research Published on:

  31. Viral load (VL) monitoring in the clinical follow-up of HIV patients to detect treatment failure is not routinely offered in Cameroon. The study was designed to characterize virological response on antiretrovi...

    Authors: Juste Patient Mbébi Enoné, Calixte Ida Penda, Serge Bruno Ebong, Madeleine Mbangue, Samuel Honoré Mandengué and Carole Else Eboumbou Moukoko
    Citation: Translational Medicine Communications 2019 4:8
    Content type: Research Published on:

  32. Tuberculosis (TB) remains a debilitating, deadly disease that warrants innovative research tools to fully understand the pathogenesis and host immune responses, particularly at the site of infection and diseas...

    Authors: Carly Young, Petri Ahlers, Andriette M. Hiemstra, Andre G. Loxton, Andrea Gutschmidt, Stephanus T. Malherbe, Gerhard Walzl and Nelita Du Plessis
    Citation: Translational Medicine Communications 2019 4:7
    Content type: Research Published on:

  33. Intraductal Papillary Mucinous Neoplasia (IPMN) are potentially malignant cystic tumors of the pancreas. IPMN can progress from low to moderate to high grade dysplasia and further to IPMN associated carcinoma....

    Authors: Mayank Saraswat, Heini Nieminen, Sakari Joenvaara, Tiialotta Tohmola, Hanna Seppänen, Ari Ristimäki, Caj Haglund and Risto Renkonen
    Citation: Translational Medicine Communications 2019 4:6
    Content type: Research Published on:

  34. Apoptosis inhibition depends on the balance between expression of some regulatory genes including Bax and c-FLIP, despite breast cancer has long been associated with disturbances in apoptosis regulation. The obje...

    Authors: Esmaeil Mahmoudi, Mahdieh Abolfathi, Naiemeh Hassanzadeh, Yaser Eshaghi Milasi, Mina Dehghani-Samani, Mansoor Khaledi, Hossein Kerdarian, Mina Najafipour and Asghar Arshi
    Citation: Translational Medicine Communications 2019 4:5
    Content type: Research Published on:

  35. The CD39/CD73/adenosine suppression pathway correlates with disease progression in patients with chronic human immunodeficiency virus 1 (HIV-1) infection; however, the relationships between this pathway in B c...

    Authors: Wen-Xian Chang, Hui-Huang Huang, Lei Huang, Ji-Jing Shi, Yan-Mei Jiao, Chao Zhang, Lei Jin, Tao Yang, Ming Shi, Bo Tu, Zhe Xu, Tian-Jun Jiang, Fu-Sheng Wang and Ji-Yuan Zhang
    Citation: Translational Medicine Communications 2019 4:4
    Content type: Research Published on:

  36. Diabetes Mellitus (DM) is a chronic disease characterized by elevated levels of glucose in the blood. With time it becomes uncontrollable and invites other complex metabolic diseases. The propensity of the peo...

    Authors: Abhinav Kanwal and Liston Augustine Dsouza
    Citation: Translational Medicine Communications 2019 4:3
    Content type: Review Published on:

  37. Although durable clinical responses are achieved in a significant number of patients given Immune checkpoint inhibitors (ICI), like anti-CTLA-4 and anti-PD-1 inhibitors, some of the cancers have shown little o...

    Authors: Puneet Singh, Paul de Souza, Kieran F. Scott, Bruce M. Hall, Nirupama D. Verma, Therese M. Becker, James W. T. Toh, Mila Sajinovic and Kevin J. Spring
    Citation: Translational Medicine Communications 2019 4:2
    Content type: Review Published on:

  38. Leptin, a pleiotropic hormone is produced by adipose tissues and plays a critical role in various biological functions. Leptin mediates its function through interaction with specific receptors. The leptin-rece...

    Authors: Iman W. Achkar, Ajaz A. Bhat, Maria Zafar, Madiha Abbas, Omar S. Khan, Shilpa Kuttikrishnan, Kirti S. Prabhu and Shahab Uddin
    Citation: Translational Medicine Communications 2019 4:1
    Content type: Review Published on:

  39. Autoimmune diseases are syndromes characterized by an immune response against self-antigens. They are complex pathologies associated with a variety of genetic determinants, but these genes cannot fully explain...

    Authors: Leydy Katherin Duque Suárez, Gerardo Quintana López, Paola Ximena Coral Alvarado, Paul Alejandro Méndez Patarroyo, Helena Groot deRestrepo and Valeriano López-Segura
    Citation: Translational Medicine Communications 2018 3:11
    Content type: Research Published on:

  40. Endothelial surface glycocalyx shedding plays a role in endothelial dysfunction and increases vessel wall permeability, which can lead to inflammation and atherogenesis. We sought to elucidate whether a high f...

    Authors: Ronodeep Mitra, Ju Qiao, Sudharsan Madhavan, Gerard L. O’Neil, Bailey Ritchie, Praveen Kulkarni, Srinivas Sridhar, Anne L. van de Ven, Erica M. Cherry Kemmerling, Craig Ferris, James A. Hamilton and Eno E. Ebong
    Citation: Translational Medicine Communications 2018 3:10
    Content type: Research Published on:

  41. Down Syndrome (DS) has a very high morbidity, according to statistics, the incidence rate of DS is as high as 1:700 among the new born babies. At present, there are still no effective prevention or treatment m...

    Authors: Weiguo Sui, Qing Gan, Wei Wei Gong, Xiaolian Wei, Minglin Ou, Donge Tang, Huanyun Jing, Hua Lin, Yue Zhang and Yong Dai
    Citation: Translational Medicine Communications 2018 3:9
    Content type: Research Published on:

  42. The Notch pathway combined with other signalling molecules acts specifically for the development of each blood cell type and differentiation stage. A causative role of Notch dysfunction in leukaemia developmen...

    Authors: Luka Horvat, Josipa Skelin, Biljana Jelić Puškarić, Isidoro Feliciello, Darko Heckel, Josip Madunić, Ika Kardum-Skelin, Maja Matulić, Delfa Radić-Krišto and Mariastefania Antica
    Citation: Translational Medicine Communications 2018 3:8
    Content type: Research Published on:

  43. GNE myopathy (distal myopathy with rimmed vacuoles) is a rare intractable muscle disease caused by the mutations in GNE gene, with no therapeutic agents at present. The mutations in GNE (UDP-N-acetylglucosamine 2...

    Authors: Naoki Suzuki, Masaaki Kato, Hitoshi Warita, Rumiko Izumi, Maki Tateyama, Hiroshi Kuroda, Ryuta Asada, Akifumi Suzuki, Takuhiro Yamaguchi, Ichizo Nishino and Masashi Aoki
    Citation: Translational Medicine Communications 2018 3:7
    Content type: Research Published on:

  44. There is no consensus therapy recommended for recurrent malignant gliomas (MGs). In 2009, Bevacizumab (BEV) was approved by the FDA as single-agent for recurrent glioblastoma (GBM). The aim of this retrospecti...

    Authors: Arsela Prelaj, Sara Elena Rebuzzi, Maurizio Salvati, Silvia Pecorari, Chiara Pozzi, Carmela Fusto, Carla Ferrara, Silverio Tomao and Vincenzo Bianco
    Citation: Translational Medicine Communications 2018 3:6
    Content type: Research Published on:

  45. A role for sex hormone-binding globulin (SHBG) in determining the pregnancy outcome was evidenced by the rise in SHBG levels during pregnancy linked with favorable pregnancy, while reduction in SHBG levels and...

    Authors: Mariam Dendana, Ramzi R. Finan, Mariam Al-Mutawa and Wassim Y. Almawi
    Citation: Translational Medicine Communications 2018 3:5
    Content type: Research Published on:

  46. It is known that rheumatoid symptoms improve in pregnancy and in patients who develop infective jaundice. The mechanism of amelioration might involve the direct interaction of free endosomal self-epitopes that...

    Authors: Innocenzo Caruso, Enzo Massimo Caruso, Salvatore Santandrea, Franco Montrone, Piercarlo Sarzi Puttini and Marco Cazzola
    Citation: Translational Medicine Communications 2018 3:4
    Content type: Research Published on:

  49. The foreign antigen that enters into the body is detected by the immune system through antigen presenting cells leading to the production of antibodies. The use of anti-idiotype antibodies is a new way to exci...

    Authors: Ahsan Naveed, Sajjad Ur Rahman, Muhammad Imran Arshad and Bilal Aslam
    Citation: Translational Medicine Communications 2018 3:1
    Content type: Review Published on:
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Translational Medicine Communications

ISSN: 2396-832X

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