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  1. Many tumors contain hypoxic microenvironments caused by inefficient tumor vascularization. Hypoxic tumors have been shown to resist conventional cancer therapies. Hypoxic cancer cells rely on glucose to meet t...

    Authors: Karen Schmidt, Amber Thatcher, Albert Grobe, Pamela Broussard, Linda Hicks, Haiwei Gu, Lesley G Ellies, Dorothy D. Sears, Leonid Kalachev and Eugene Kroll
    Citation: Translational Medicine Communications 2024 9:21
  2. Rett syndrome (OMIM 312750) is a rare neurodevelopmental disorder caused by de novo mutations in the Methyl-CpG Binding Protein 2 (MeCP2) gene located on the X-chromosome, typically affecting girls. Rett syndr...

    Authors: Rodrigo Lata, Liesbeth Steegmans, Ranie Kellens, Marnik Nijs, Hugo Klaassen, Matthias Versele, Frauke Christ and Zeger Debyser
    Citation: Translational Medicine Communications 2024 9:20
  3. SARS-CoV-2 caused an outbreak in late December 2019. It has been suggested that gut microbiota dysbiosis influences the severity, mortality, and quality of life of patients with COVID-19. So, identifying the g...

    Authors: Seyed Aria Nejadghaderi, Ehsan Nazemalhosseini-Mojarad, Asra Fazlollahi, Ali Pirsadeghi, Ainaz Khalili, Rasoul Ebrahimi and Nima Rezaei
    Citation: Translational Medicine Communications 2024 9:19
  4. We aimed to investigate the development of synovial fibrosis in vitro and how the fibrosis can be halted. Synovial fibrosis causes joint stiffness in arthritic diseases. The pathway of the fibrotic growth fact...

    Authors: Sofie Falkenløve Madsen, Sarah Spliid Madsen, Alexander Scheller Madrid, Mikkel Rathsach Andersen, Anne-Christine Bay-Jensen and Christian S. Thudium
    Citation: Translational Medicine Communications 2024 9:18
  5. Tissue engineering is a multidisciplinary field that combines principles from cell biology, bioengineering, material sciences, medicine and surgery to create functional and viable bioproducts that can be used ...

    Authors: Renan Gonçalves Leonel da Silva, Larry Au and Alessandro Blasimme
    Citation: Translational Medicine Communications 2024 9:17
  6. Uterus tissue engineering aims to repair a dysfunctional uterus that causes infertility, e.g., after significant scarring from benign or malign resection procedures. Decellularized uterine tissue provided rege...

    Authors: Edina Sehic, Lucía de Miguel-Gómez, Emy Thorén, Johan Sameus, Henrik Bäckdahl, Mihai Oltean, Mats Brännström and Mats Hellström
    Citation: Translational Medicine Communications 2024 9:16
  7. Immune Checkpoint Inhibitor (ICI) immunotherapy is most effective in immune effector cell infiltrated ‘hot’ tumor lesions, such as occurs in deficient mismatch repair, microsatellite instability high (dMMR/MSI...

    Authors: Ariel Hirschfeld, Daniel Gurell and Michael Har-Noy
    Citation: Translational Medicine Communications 2024 9:15
  8. Pancreatic cancer (PC) remains a significant healthcare challenge due to its aggressive nature and poor prognosis. The current gold standard that combines imaging modalities, endoscopy, and biopsies has limite...

    Authors: Federica Dibennardo, Onur Fidaner, Les Bogdanowicz, Daniel S. Gehrke, Donato Ceres, Margaret C. John, Constantine H. Bovalis, Erik M. Kundro, Alexander Grycuk, Karla Castellanos, Adonis Coleman, Kavya Sudhir, Jorge Heneche, Jose Acebedo, Angel Jimenez, Isaac Raijman…
    Citation: Translational Medicine Communications 2024 9:14
  9. In recent years, there has been a noteworthy increase in research exploring the relationship between gut microbiota and bariatric surgery. This increase can be attributed to the growing recognition of the impo...

    Authors: Sa’ed H. Zyoud, Muna Shakhshir, Abdelkarim Barqawi, Amani S. Abushanab, Amer Koni, Shadi Khilfeh, Moyad Shahwan, Ammar A. Jairoun, Adham Abu Taha, Faris Abushamma and Samah W. Al-Jabi
    Citation: Translational Medicine Communications 2024 9:13
  10. Parkinson’s disease (PD) is a prevalent neurodegenerative disorder affecting millions of elderly individuals worldwide. Clinically, PD is diagnosed based on the presentation of motoric symptoms. Other methods ...

    Authors: Teddy J. W. Tng, Barbara Wing Yan Wong, Esther H. Y. Sim, Eng King Tan, Wilson W. B. Goh and Kah-Leong Lim
    Citation: Translational Medicine Communications 2024 9:12
  11. The COVID-19 pandemic and the consequences of safety measures, such as lockdowns, have impacted not only the physical health of individuals but also their lifestyle, psychosocial health, and mental health. In ...

    Authors: Amer A. Koni, Israa Hasan, Maisa A. Nazzal, Siwar Haj, Hamza K. Joma, Amani S. Abushanab and Sa’ed H. Zyoud
    Citation: Translational Medicine Communications 2024 9:11
  12. Eosinophilic esophagitis (EoE) is a chronic inflammatory condition characterized by an intense infiltration of eosinophils into the esophageal epithelium. When not adequately controlled, eosinophilic inflammat...

    Authors: Ezekiel J. Haugen, Andrea K. Locke, Hernán Correa, Justin S. Baba, Anita Mahadevan-Jansen and Girish Hiremath
    Citation: Translational Medicine Communications 2024 9:10
  13. SARS-CoV-2 belongs to the coronaviridae family and infects human cells by directly interacting with the angiotensin-converting enzyme-2 (ACE-2) through the viral Spike Protein (SP). While vaccines are crucial, mu...

    Authors: Alessandro Del Re, Silvia Basili Franzin, Jie Lu, Irene Palenca, Aurora Zilli, Federico Pepi, Anna Troiani, Luisa Seguella, Marcella Pesce, Giovanni Esposito, Giovanni Sarnelli and Giuseppe Esposito
    Citation: Translational Medicine Communications 2024 9:9
  14. Kidney stones, or renal nephrolithiasis, are common and dangerous, increasing the risk of chronic kidney disease. Dietary manipulation is essential for the prevention and recurrence of kidney stones. Research ...

    Authors: Sa’ed H. Zyoud, Faris Abushamma, Husam Salameh, Amani S. Abushanab, Amer Koni, Adham Abu Taha, Samah W. Al-Jabi, Moyad Shahwan, Ammar A. Jairoun and Muna H. Shakhshir
    Citation: Translational Medicine Communications 2024 9:8
  15. Insulin resistance is a major pathogenic factor that plays a crucial role in the development of metabolic syndrome and has been proposed as one of its underlying causes. Most diagnostic criteria for metabolic ...

    Authors: Sa’ed H. Zyoud, Muna Shakhshir, Amani S. Abushanab, Amer Koni, Moyad Shahwan, Ammar A. Jairoun, Adham Abu Taha, Faris Abushamma and Samah W. Al-Jabi
    Citation: Translational Medicine Communications 2024 9:6
  16. Dysregulation of cellular processes related to protein folding and trafficking leads to the accumulation of misfolded proteins in the endoplasmic reticulum (ER), triggering ER stress. Cells cope with ER stress...

    Authors: Fernanda Dittrich Oliveira, Rafael Paschoal de Campos, Luiza Cherobini Pereira, Lisiane B. Meira and Guido Lenz
    Citation: Translational Medicine Communications 2024 9:5
  17. The 26S proteasome is a large intracellular multiprotein complex, that plays a homeostatic role by degrading proteins that have been tagged by ubiquitin. It is composed of 64 subunits assembled according to a ...

    Authors: Vito Spataro and Antoine Buetti-Dinh
    Citation: Translational Medicine Communications 2024 9:4
  18. Arsenic (ATO) and retinoic acid (ATRA) are successfully used as chemotherapy-free regimens to treat acute APL. Compared to traditional chemotherapy approaches, this therapy evokes fewer haematological side eff...

    Authors: Anna Thunström Salzer and Constantin F. Urban
    Citation: Translational Medicine Communications 2024 9:3

    The Correction to this article has been published in Translational Medicine Communications 2024 9:7

  19. iMN013 (5-aza-2',2'-difluorodeoxycytidine), a DNA methyl transferase inhibitor and ribonucleotide reductase inhibitor, and its prodrug iMN041 (3',5'-di-trimethylsilyl-2',2'-difluro-5- azadeoxycytidine), have b...

    Authors: Richard Daifuku, Yu Zhang, Jingjing Wang and Qingyang Gu
    Citation: Translational Medicine Communications 2024 9:2
  20. Late-stage human immunodeficiency virus (HIV) infection is typically characterized by low CD4 + T-cell count. We previously showed that profound changes in the monocyte turnover (MTO) rate in rhesus macaques i...

    Authors: Laurent Zablocki-Thomas, Amir Ardeshir, Naofumi Takahashi, Kevin S. White, Cinar Efe Sumer, Zoey K. Wallis, Elizabeth S. Didier, Woong-Ki Kim, Kenneth C. Williams and Marcelo J. Kuroda
    Citation: Translational Medicine Communications 2024 9:1
  21. Androgenetic alopecia (AGA), one of the most common types of hair loss, is associated with oxidative stress, inflammation and aging. Derinat, a transient receptor potential canonical channels (TRPCs) inhibitor...

    Authors: Ching-Ying Wu, Wei-Chiao Chen, Cheng-Hsu Hsieh, Yun-Fang Liang, Wei-Ju Li, Hao Shen, Wei-Yen Wei, Ting-Yu Chou, Yen-Chun Chiu, Hao Huang and Wen-Li Hsu
    Citation: Translational Medicine Communications 2023 8:25
  22. Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited condition associated primarily with PKD1 and PKD2 genes. However, ADPKD patients in Latin America have had limited access to comprehensiv...

    Authors: Esperanza Bayyad, Anita Plaza, Jaime Klenner, Patricio Downey, Paulina Salas, Daniela Maragaño, Patricio Herrera, Paula Lehmann, Lily Quiroz, María Jesus Zavala, Karen Orostica, Claudio Flores, Leopoldo Ardiles, Jorge Maturana and Paola Krall
    Citation: Translational Medicine Communications 2023 8:24
  23. The blood-labyrinth barrier (BLB) separates the inner ear from the circulation and is critical for maintaining ionic homeostasis and limiting the entry of deleterious agents. BLB integrity is disrupted by bact...

    Authors: Silvia Murillo-Cuesta, Ester Lara, Jose M. Bermúdez-Muñoz, Elena Torres-Campos, Lourdes Rodríguez-de la Rosa, Pilar López-Larrubia, Signe R. Erickson and Isabel Varela-Nieto
    Citation: Translational Medicine Communications 2023 8:23
  24. Escherichia coli is a facultative anaerobic bacterium that normally resides in the gastrointestinal tract of humans and animals but can cause diarrhea and enteritis. MPX is an antimicrobial peptide extracted from...

    Authors: Xueqin Zhao, Weiyu Luo, Lei Wang, Chunling Zhu, Xianghong Xue, Xiaojing Xia, Xilong Wu, Yueyu Bai and Jianhe Hu
    Citation: Translational Medicine Communications 2023 8:22
  25. Clonal hematopoiesis (CH) describes the aging-associated expansion of mutant hematopoietic cell populations. In various cohorts, CH has been associated with increased morbidity and mortality from non-hematolog...

    Authors: Cathy Smith, Bala B. Burugula, Morgan A. Jones, Qing Li, Jacob O. Kitzman and Terrence N. Wong
    Citation: Translational Medicine Communications 2023 8:20
  26. A gluten-free diet (GFD) has become one of the most popular eating plans and is essential for managing gluten-related medical conditions, signs, and symptoms. Therefore, we performed a bibliometric analysis of...

    Authors: Sa ’ed H. Zyoud, Muna Shakhshir, Amani S. Abushanab, Amer Koni, Moath Hamdallah and Samah W. Al-Jabi
    Citation: Translational Medicine Communications 2023 8:18
  27. Despite the successes of checkpoint inhibitors targeting T-cell receptors, clinical efficacy is highly cancer-dependent and subject to high inter-individual variability in treatment outcome. The ability to pre...

    Authors: Juan Miguel Tenorio-Pedraza, Jörg Lippert, Rolf Burghaus and Christian Scheerans
    Citation: Translational Medicine Communications 2023 8:17
  28. Media fills are used to demonstrate the adequacy of the aseptic conditions of a pharmaceutical production process, according to good manufacturing practice (GMP), using a growth medium in place of the product ...

    Authors: Ivana Ferrero, Sara Castiglia, Aloe Adamini, Alessandra Mandese, Francesca Sismondi, Deborah Rustichelli, Marco Leone, Giuseppe Pinnetta, Lucia Giordanengo, Katia Mareschi and Franca Fagioli
    Citation: Translational Medicine Communications 2023 8:16
  29. Gene-modified cell therapy with regulatory T cells (Tregs) is a promising approach to prevent graft rejection and induce immunological tolerance in organ transplantation. We are developing a cell therapy compr...

    Authors: Hervé Bastian, Nadia Lounnas-Mourey, Pierre Heimendinger, Benjamin L. Hsu, Katharina H. Schreeb, Claire Chapman, Emily Culme-Seymour, Gillian F. Atkinson and Diego Cantarovich
    Citation: Translational Medicine Communications 2023 8:15
  30. Early dysregulation of local and systemic inflammatory and immune responses is implicated in the pathogenesis of fibrotic and degenerative complications after anterior cruciate ligament reconstruction (ACLR) s...

    Authors: Jodie L. Morris, Peter C. McEwen, Hayley L. Letson and Geoffrey P. Dobson
    Citation: Translational Medicine Communications 2023 8:14
  31. Management of mechanically ventilated patients can be improved with monitoring of key pulmonary function parameters that facilitate individualization and optimization. The VQm Pulmonary Health Monitor™ (PHM) (...

    Authors: Maximilian Edlinger-Stanger, Caroline Fritz, Hanna C. McGregor, Spencer L. Bustin, Nathan Ayoubi, Harpreet K. Bath, Johannes Müller, Sebastian Kühnl-Brady, Thomas Schweiger, Julia Jedamzik, Marita Windpassinger, Michael Hiesmayr, Bernard P. Cholley and Neal W. Fleming
    Citation: Translational Medicine Communications 2023 8:13
  32. Cumulative research show association of neutrophils and neutrophil extracellular traps (NETs) with poor outcomes in severe COVID-19. However, to date, there is no curative intent therapy able to block neutroph...

    Authors: Victoria L. M. Herrera, Nicholas A. Bosch, Judith J. Lok, Mai Q. Nguyen, Kaitriona A. Lenae, Joanne T. deKay, Sergey V. Ryzhov, David B. Seder, Nelson Ruiz-Opazo and Allan J. Walkey
    Citation: Translational Medicine Communications 2023 8:12
  33. Gene therapy manipulates or modifies a gene that provides a new cellular function to treat or correct a pathological condition, such as cancer. The approach of using gene manipulation to modify patient’s cells...

    Authors: Shivani Thoidingjam, Sushmitha Sriramulu, Svend Freytag, Stephen L. Brown, Jae Ho Kim, Indrin J. Chetty, Farzan Siddiqui, Benjamin Movsas and Shyam Nyati
    Citation: Translational Medicine Communications 2023 8:11
  34. Rheumatoid Arthritis is one of the most common autoimmune diseases, causing irreversible joint damage and disability. Methotrexate (MTX) is the gold standard drug for this. The low cost, easy availability and ...

    Authors: Harjit Singh Nalwa, Peeyush Prasad, Nirmal Kumar Ganguly, Ved Chaturvedi and Shivani Arora Mittal
    Citation: Translational Medicine Communications 2023 8:10
  35. Preclinical studies have demonstrated the potential use of induced pluripotent stem cells (iPSCs) to treat cardiovascular disease (CVD). In vivo preclinical studies conducted on animal models (murine, porcine,...

    Authors: Ryan Bellman, Jishizhan Chen, Lidan Chen, Nikolitsa Nomikou, Janice Tsui, George Hamilton and Wenhui Song
    Citation: Translational Medicine Communications 2023 8:9
  36. Host response to the human immune deficiency virus (HIV) involves both the innate and adaptive immune systems. As part of the innate immune system, the killer cell immunoglobulin-like receptors (KIRs) found o...

    Authors: John Mukisa, Marion Amujal, Obondo J. Sande, Moses L. Joloba, Daudi Jjingo, David P. Kateete, Graeme Mardon, Mogomotsi Matshaba, Neil Hanchard and Jill A. Hollenbach
    Citation: Translational Medicine Communications 2023 8:8
  37. Electronic health records (EHRs) and linked biobanks have tremendous potential to advance biomedical research and ultimately improve the health of future generations. Repurposing EHR data for research is not w...

    Authors: Cosby G. Arnold, Brandon Sonn, Frederick J. Meyers, Alexis Vest, Richie Puls, Estelle Zirkler, Michelle Edelmann, Ian M. Brooks and Andrew A. Monte
    Citation: Translational Medicine Communications 2023 8:7
  38. Prophylactic platelet transfusion is given to patients when the platelet count is less than ten thousand to prevent clinically significant bleeding till platelet engraftment is documented. Despite a very low p...

    Authors: Zainab Ghias, Uzma Zaidi, Munira Borhany, Shafaq Abdul Samad, Noureen Durrani, Mushkbar Fatima, Sidra Zafar, Aisha Jamal and Tahir Shamsi
    Citation: Translational Medicine Communications 2023 8:6
  39. This window of opportunity trial evaluated the safety of intratumoral Copaxone® and profiled immune markers in biopsies before and after treatment.

    Authors: Joaquina C. Baranda, Ghulam Rehman Mohyuddin, Andrés M. Bur, Yelizaveta Shnayder, Kyle R. Sweeney, Kiran Kakarala, Megan Prouty, Harsh Pathak, Rajni Puri, Amrita Mitra, Rashna Madan, M. Laird Forrest, Aric Huang, Scott Weir, Andrew K. Godwin, Nabil A. Alhakamy…
    Citation: Translational Medicine Communications 2023 8:5
  40. Intrathecal (IT) catheter delivery of baclofen via continuous infusion using an implantable pump is an important means of treating patients with severe spasticity. We evaluated the impact of IT catheter tip pl...

    Authors: Brian A. Duclos, Cindy Roegge, Howard Dobson, Scott Haller, Jeff Bodner, Sanjana Pannem, Janelle Gesaman and Amin Nourmohammadi
    Citation: Translational Medicine Communications 2023 8:4
  41. The BRAF and MEK inhibitors combined strategies have dramatically changed the outcome of BRAF-mutated metastatic melanoma patients. However, despite the initial promising results, the onset of primary or acqui...

    Authors: Valentina Belli, Stefania Napolitano, Vincenzo De Falco, Gabriella Suarato, Alessandra Perrone, Luigi Pio Guerrera, Giulia Martini, Carminia Maria Della Corte, Erika Martinelli, Floriana Morgillo, Mimmo Turano, Maria Furia, Giuseppe Argenziano, Davide Ciardiello, Fortunato Ciardiello and Teresa Troiani
    Citation: Translational Medicine Communications 2023 8:3
  42. Hypoxic zones exist in solid tumors, where oxygen levels are significantly lower than in normal tissues. Hypoxia makes chemo-radiation therapeutics less effective and renders the metastatic potential more favo...

    Authors: Muzamil Farooq, Gh. Rasool Bhat, Syed Besina, Natasha Thakur, Sheikh Zahoor, Rafiq A. Rather, Ifra Mushtaq, Sadaf Dar, Bilal Rah, Ajaz A. Bhat, Muzafar A. Macha and Dil Afroze
    Citation: Translational Medicine Communications 2023 8:2
  43. RLS-0071 is a novel 15 amino acid peptide dual-targeting anti-inflammatory inhibitor of complement and neutrophil effectors. RLS-0071 inhibits classical complement pathway activation at C1 and blocks the enzym...

    Authors: Jessica Goss, Pamela Hair, Parvathi Kumar, Giuseppina Iacono, Laura Redden, Gaetano Morelli, Neel Krishna, Ulrich Thienel and Kenji Cunnion
    Citation: Translational Medicine Communications 2023 8:1
  44. Acute inflammation is the body’s immediate and well-coordinated response to injury, which if not resolved can lead to a state of chronic inflammation and is an important component of aging-associated pathologi...

    Authors: Asha Jaja-Chimedza, Steven Hirsh, Dainian Bruce, Tony Bou-Sliman, Steven Joyal and Andrew G. Swick
    Citation: Translational Medicine Communications 2022 7:25
  45. Clinical translation from bench to bedside often remains challenging even despite promising preclinical evidence. Among many drivers like biological complexity or poorly understood disease pathology, preclinic...

    Authors: Natascha Ingrid Drude, Lorena Martinez-Gamboa, Meggie Danziger, Anja Collazo, Silke Kniffert, Janine Wiebach, Gustav Nilsonne, Frank Konietschke, Sophie K. Piper, Samuel Pawel, Charlotte Micheloud, Leonhard Held, Florian Frommlet, Daniel Segelcke, Esther M. Pogatzki-Zahn, Bernhard Voelkl…
    Citation: Translational Medicine Communications 2022 7:24
  46. Diabetic dyslipidemia is a complex multidimensional abnormality. However, earlier studies did not focus on the prevalence of various patterns of dyslipidemia. We categorized dyslipidemia into three groups. Sin...

    Authors: Amirhossein Yadegar, Fatemeh Mohammadi, Soghra Rabizadeh, Reihane Qahremani, Alireza Esteghamati and Manouchehr Nakhjavani
    Citation: Translational Medicine Communications 2022 7:23

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